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Molecular Interaction Core

The mission of the Molecular Interaction Core is to study the intermolecular interactions in real time to determine association and dissociation kinetics utilizing Biacore technology (www.biacore.com) and to perform concentration analysis. The Core is located at the Research Institute for Children (Children’s Hospital Campus).

Services include Biacore technology that has proven useful in determining affinities of monoclonal antibodies and of polyclonal antisera. Because antibody affinity is often a correlate of protective activity, this presents a method for analyzing the quality of the antibody response elicited by experimental vaccines. Other uses for this technique include defining interactions between peptides and other low molecular weight ligands and larger molecules including antibodies, receptors, and enzymes.

The Molecular Interaction Core is directed by Seth Pincus MD and Miriam Corti PhD.

Click here for Molecular Interaction CoreSlide Show.